In May 2012, Maryville University launched two online graduate Nursing programs. Eighteen months later, 1,700 students from across the United States were enrolled as online-only students in these programs. Two additional Nursing graduate programs are going online as well as an MBA program. Concurrently, Library space is being reconfigured to accommodate student support services from other areas and to provide more learning spaces for students. With less space for physical collections and more students to support, we are trying to find a way to provide better research support for all our students. How Maryville is handling these challenges and their impact on all aspects of library service (collection development, reference, interlibrary loan, budgeting, staffing, etc.) will be discussed.